Programmable assembly of hybrid colloidal microswimmers
Songbo Ni1,2, Miguel Angel Fernandez Rodriguez1,2, Jessica Leemann1,2, Emanuele Marini1,2, Ivo Buttinoni2, Laura Alvarez-Frances2, Christian Schwemmer1, Armin Knoll1, Lucio Isa2, Heiko Wolf1
1IBM Research – Zurich, Säumerstrasse 4, 8803 Rüschlikon, Switzerland.
2Laboratory for Interfaces, Soft Matter and Assembly, Department of Materials, ETH Zurich, Vladimir-Prelog-Weg 5, 8093 Zurich, Switzerland.
We use sequential capillarity-assisted particle assembly (sCAPA) to link microspheres of different materials into hybrid colloidal clusters of designed shapes that can actively translate, circulate and rotate powered by asymmetric electro-hydrodynamic flows. We characterize the active motion of the clusters in a vertical AC electric field and discuss how composition and shape can be used to tune their trajectories.
Evening Lecture (7:00 – 8:00 p.m.)
A perfectly engineered functional interface – how the deadly African trypanosomes fool our immune response
Markus Engstler, Department of Cell and Developmental Biology, Biocenter, University of Wuerzburg, Germany, http://www.zeb.biozentrum.uni-wuerzburg.de
For more than hundred years, scientists have tried to defeat African sleeping sickness, without any success. This is probably due to the unusual evolution of the infectious agent, the trypanosome, a single-celled parasite that has had 500 million years’ time to engineer a protective surface coat, which is highly multi-functional, variable, dynamic and impervious. I will put our high-end research in the context of the huge socio-political problem of neglected tropical diseases of poverty.
Keynote Lecture I (8:30 – 9:00 a.m.)
Electrochemical micro/nano fabrication processes – Process development and mechanistic understanding –
Takayuki Homma, Department of Applied Chemistry, Waseda University, Okubo, Shinjuku, Tokyo 169-8555, Japan
Electrochemical deposition and etching are key processes to fabricate functional micro/nano structures and devices, featuring their precise controllability and uniformity for wide, non-flat surfaces. This paper introduces recent topics of these processes, together with molecular-level experimental and theoretical approaches to analyze their interfacial reaction processes for mechanistic understanding to achieve further precise control.
Keynote Lecture II (11:30 – 12.00 a.m.)
Enzyme mediated autodeposition
Oliver I. Strube, Biobased & Bioinspired Materials, Paderborn University, Germany
This talk addresses a novel technology for material design on surfaces: The Enzyme Mediated Autodeposition. Key aspect of this highly precise, flexible, and easy-to-apply approach is an enzymatic reaction in direct proximity to the support surface. This reaction induces immediate and precise addressing of particles. Resulting deposition patterns range from µm–coatings with defined parameters to nanostructures of single particles.
Keynote Lecture III (3:30 – 4.00 a.m.)
Engineering functional DNA nanostructures at semifluid membrane interfaces
Stefan Howorka, University College London, Department of Chemistry, London WC1H0AJ, UK, firstname.lastname@example.org
Semifluid membranes enclose all cells and organelles, encapsulate drugs and imaging agents, and provide a platform for biosensing. In my talk, I report on how the two key membrane properties of permeability and shape can be controlled with rationally designed DNA nanostructures. I will give examples on where the new approach is of interest for synthetic biology and nanobiotechnology.
Keynote Lecture IV (8:30 – 9:00 a.m.)
Optical antennas for the development of smartphone based point of care devices with single molecule sensitivity
Dr. Guillermo Acuna, Institute for Physical & Theoretical Chemistry, and Braunschweig Integrated Centre of Systems Biology (BRICS), and Laboratory for Emerging Nanometrology (LENA), Braunschweig University of Technology, 38106 Braunschweig, Germany, email@example.com
Smartphone-based devices (SBDs) are the most promising candidates for the development of next-next generation POC diagnostics platforms. However, SBDs fail to perform on a similar level as established bench-top based analytical tools and are not able to detect for example low-abundant analytes. In this contribution we show that self-assembled optical antennas based on the DNA origami technique can enhance fluorescence by a factor of 5000. We exploit this effect to detect single molecules with a smartphone-based microscope.